CHARACTERIZATION OF MATERIALS

Deeken CR,  Abdo MS, Frisella MM, Matthews BD Physicomechanical evaluation of  absorbable and nonabsorbable barrier composite meshes for laparoscopic  ventral hernia repair. Surg Endosc (2011) 25:1541-1552 PubMed PMID:  20976479

Deeken CR,  Abdo MS, Frisella MM, Matthews BD Physicomechanical evaluation of  polypropylene, polyester, and polytetrafluoroethylene meshes for  inguinal hernia repair. 

J Am Coll Surg (2011) Jan; 212(1):68-79 PubMed PMID: 21115372

Eliason BJ, Frisella MM, Matthews BD, Deeken CR

Effect of repetitive loading on the mechanical properties of synthetic hernia repair materials. J Am Coll Surg 2011 Sept;213(3)430-435

Lerdsirisopon S, Frisella MM, Matthews BD, Deeken CR Biomechanical evaluation of potential damage to hernia repair materials due to fixation with helical titanium tacks. 

Surg Endosc (2011) 25(12):3890-3897

Deeken CR, Faucher KM, Matthews BD 

A  review of the composition, characteristics, and effectiveness of  barrier mesh prostheses utilized for laparoscopic ventral hernia repair.  Surg Endosc (2012) 26:566-575 PubMed PMID: 21898010

Deeken CR,  Eliason BJ, Pichert MD, Grant SA, Frisella MM, Matthews BD  Differentiation of biologic scaffold materials through  physicomechanical, thermal, and enzymatic degradation techniques. Annals  of Surgery (2012)255(3):595-604 PubMed PMID: 22314328

Pui CL, Tang ME, Annor AH, Ebersole GC, Frisella MM, Matthews BD, Deeken CR Effect of repetitive loading on the mechanical properties of biological scaffold materials. J Am Coll Surg (2012) 215:216-228

 Annor AH, Tang ME, Pui CL, Ebersole GC, Frisella MM, Matthews BD, Deeken CR  Effect of enzymatic degradation on the mechanical properties of  biological scaffold materials. Surg Endosc (2012) 26:2767-2778 (PMCID:  PMC3702043)

Deeken CR, Thompson Jr. DM, Castile RM, Lake SP 
Biaxial  analysis of synthetic scaffolds for hernia repair demonstrates  variability in mechanical anisotropy, non-linearity and hysteresis.  JMBBM; 2014 38:6-16

Lake SP, Ray S, Zihni AM, Thompson Jr DM, Gluckstein J, Deeken CR Pore  size and pore shape – but not mesh density – alter the mechanical  strength of tissue ingrowth and host tissue response to synthetic mesh  materials in a porcine model of ventral hernia repair. JMBBM (2014)  42:186-197. 

Zihni AM, Cavallo JA, Thompson Jr DM, Chowdhury NH, Frisella MM, Matthews BD, Deeken CR Evaluation of absorbable mesh fixation devices at various deployment angles. Surg Endosc (2015)  Jun; 29(6)1605-1613

Est SE, Roen M, Chi T, Simien A, Castile R, Thompson, Jr DM, Blatnik J, Deeken CR, Lake SP. Multi-directional mechanical analysis of synthetic scaffolds for hernia repair. JMBBM (2017) Feb 9;71:43-53. 

Deeken CR, Lake SP. Mechanical properties of the abdominal wall and biomaterials utilized for hernia repair. JMBBM (2017) 411-427.

ANALYSIS OF EXPLANTED BIOMATERIALS

Costello CR,  Bachman SL, Grant SA, Cleveland DS, Loy TS, Ramshaw BJ Characterization  of heavyweight and lightweight polypropylene prosthetic mesh explants  from a single patient. Surg Innov (2007) Sept;14(3):168-176 PubMed PMID:  17928615

Costello CR,  Bachman SL, Ramshaw BJ, Grant SA Materials characterization of  explanted polypropylene hernia meshes. J of Biomed Mater Res Part B  (2007) Oct;83B(1):44-49 PubMed PMID: 17285608

Cavallo JA, Roma AA, Jasielec MS, Ousley J, Creamer J, Pichert MD, Baalman S, Frisella MM, Matthews BD, Deeken CR  Remodeling characteristics and collagen distribution in synthetic mesh  materials explanted from human subjects after abdominal soft tissue  reconstruction: An analysis of remodeling characteristics by patient  risk factors and surgical site classifications. Surgical Endoscopy; 2014  28(6):1852-1865

Poppler L, Cohen J, Dolen UC, Schriefer AE, Tenenbaum MM, Deeken C,  Chole RA, Myckatyn TM. Histologic, molecular, and clinical evaluation  of explanted breast prostheses, capsules, and acellular dermal matrices  for bacteria. Aesthet Surg J (2015) Aug;35(6)653-668. 

Cavallo JA, Roma AA, Jasielec MS, Ousley J, Creamer J, Pichert MD, Baalman S, Frisella MM, Matthews BD, Deeken CR Remodeling  characteristics and collagen distribution in biological scaffold  materials explanted from human subjects after abdominal soft tissue  reconstruction. Annals of Plastic Surgery (2015) Jul; 75(1)74-83

Myckatyn TM, Cavallo JA, Sharma K, Gangopadhyay N, Dudas J, Roma AA, Baalman S, Tenenbaum MM, Matthews BD, Deeken CR  The impact of chemotherapy and radiation on the remodeling of acellular  dermal matrices in staged, prosthetic breast reconstruction. Plast  Reconstr Surg (2015) Jan;135(1):43e-57e.

Cavallo  JA, Gangopadhyay N, Dudas J, Roma AA, Jasielec MS, Baty J, Baalman S,  Frisella MM, Tenenbaum MM, Myckatyn TM, Matthews BD, Deeken CR.  Remodeling characteristics and collagen distributions of biologic  scaffold materials biopsied from postmastectomy breast reconstruction  sites. Annals of Plastic Surgery (2015) Jul; 75(1)74-83. PubMed PMID:  25910026

​ANIMAL MODELS

Jenkins ED, Melman L, Frisella MM, Deeken CR,  Matthews BD Evaluation of acute fixation strength of absorbable and  nonabsorbable barrier coated mesh secured with fibrin sealant. Hernia  (2010)Oct;14(5):505-509

Jenkins ED, Melman L, Deeken CR,  Greco SC, Frisella MM, Matthews BD Evaluation of fenestrated and  non-fenestrated biologic grafts in a porcine model of mature ventral  incisional hernia repair. Hernia (2010) Dec;14(6):599-610

 Melman L, Jenkins ED, Deeken CR,  Brodt MD, Brown SR, Brunt LM, Eagon JC, Frisella MM, Matthews BD  Evaluation of acute fixation strength for mechanical tacking devices and  fibrin sealant versus polypropylene suture for laparoscopic ventral  hernia repair. Surg Innov (2010) Dec;17(4):285-290

Jenkins ED, Melman L, Desai S, Brown SR, Frisella MM, Deeken CR,  Matthews BD Evaluation of intraperitoneal placement of absorbable and  nonabsorbable barrier coated mesh secured with fibrin sealant in a New  Zealand White rabbit model. Surg Endosc (2011) Feb; 25(2):604-612

Jenkins ED, Melman L, Deeken CR,  Greco SC, Frisella MM, Matthews BD Biomechanical and histological  evaluation of fenestrated and non-fenestrated biologic mesh in a porcine  model of ventral hernia repair. J Am Coll Surg (2011) Mar;  212(3)327-399 (PMCID: PMC3783002)

Melman L, Jenkins ED, Hamilton NA, Bender LC, Brodt MD, Deeken CR,  Greco SC, Frisella MM, Matthews BD Early biocompatibility of  crosslinked and non-crosslinked biologic meshes in a porcine model of  ventral hernia repair. Hernia (2011) 15(2):157-164 (PMCID: PMC3783088)

Deeken CR,  Melman L, Jenkins ED, Greco SC, Frisella MM, Matthews BD Histologic and  biomechanical evaluation of crosslinked and non-crosslinked biologic  meshes in a porcine model of ventral hernia repair. J Am Coll Surg  (2011) 212(5): 880-888 (PMCID: PMC3782991)

Melman L, Jenkins ED, Hamilton NA, Bender LC, Brodt MD, Deeken CR,  Greco SC, Frisella MM, Matthews BD Histologic and biomechanical  evaluation of a novel macroporous PTFE knit mesh compared to lightweight  and heavyweight polypropylene mesh in a porcine model of ventral hernia  repair. Hernia (2011)15(4):423-431

Jenkins ED, Lerdsirisopon S, Costello KP, Melman L, Greco SC, Frisella MM, Matthews BD, Deeken CR Laparoscopic  fixation of biologic mesh at the hiatus with fibrin or polyethylene  glycol (PEG) sealant in a porcine model. Surg Endosc (2011)25;10:  3405-3413

Jenkins ED, Melman L, Desai S, Deeken CR,  Greco SC, Frisella MM, Matthews BD Histologic evaluation of absorbable  and nonabsorbable barrier coated mesh secured to the peritoneum with  fibrin sealant in a New Zealand White rabbit model. Hernia (2011)  Dec;15(6):677-684

Deeken CR,  Melman L, Jenkins ED, Greco SC, Frisella MM, Matthews BD Reply to  comments regarding: Histologic and biomechanical evaluation of  crosslinked and non-crosslinked biologic meshes in a porcine model of  ventral hernia repair. J Am Coll Surg (2011) 213: 692

Deeken CR,  Matthews BD Comparison of contracture, adhesion, tissue ingrowth, and  histologic response characteristics of permanent and absorbable barrier  meshes in a porcine model of laparoscopic ventral hernia repair. Hernia  (2012)16(1):69-76 PubMed PMID: 21748478

Cavallo JA, Greco SC, Liu J, Frisella MM, Deeken CR,  Matthews BD Remodeling characteristics and biomechanical properties of a  crosslinked versus a non-crosslinked porcine dermis scaffolds in a  porcine model of ventral hernia repair. Hernia (e-pub 01 March 2013) doi  10.1007/s10029-013-1070-2

Deeken CR,  Matthews BD Characterization of the mechanical strength, resorption  properties, and histologic characteristics of a fully absorbable  material (Poly-4-hydroxybutyrate-PHASIX Mesh) in a porcine model of  hernia repair. ISRN Surg ,Vol 2013, pages 1-12, article ID 238067.  PMCID: PMC3679684

Deeken CR,  Matthews BD Ventralight ST & SorbaFix vs. Physiomesh &  Securestrap in a porcine model. JSLS (2013)17:549-559. PubMed PMID:  24398196

Lake SP, Ray S, Zihni AM, Thompson Jr DM, Gluckstein J, Deeken CR  Pore size and pore shape – but not mesh density – alter the mechanical  strength of tissue ingrowth and host tissue response to synthetic mesh  materials in a porcine model of ventral hernia repair. JMBBM 42 (2014)  186-197.

Scott JR, Deeken CR,  Martindale RG, Rosen MJ. Evaluation of a fully absorbable  poly-4-hydroxybutyrate/absorbable barrier composite mesh in a porcine  model of ventral hernia repair. Surg Endosc (2016) Sep;30(9):3691-3701.  PubMed PMID: 27369286

 Stoikes NFN, Scott JR, Badhwar A, Deeken CR,  Voeller GR. Characterization of host response, resorption, and strength  properties, and performance in the presence of bacteria for  fully-absorbable biomaterials for soft tissue repair. Hernia (2017)  21:771-782.

DESIGN OF NOVEL BIOMATERIALS

Deeken CR,  Esebua M, Bachman SL, Ramshaw BJ, Grant SA Assessment of the  biocompatibility of two novel, bionanocomposite scaffolds in a rodent  model. J Biomed Mater Research: Part B (2011) Feb; 96B(2):351-359 PubMed  PMID: 21210419

Deeken CR,  White AK, Bachman SL, Ramshaw BJ, Cleveland DS, Loy TS, Grant SA Method  of preparing a decellularized porcine tendon using tributyl phosphate. J  Biomed Mater Research: Part B (2011) Feb;96B(2):199-206 PubMed PMID:  21210498

Deeken CR,  Cozad MJ, Bachman SL, Ramshaw BJ, Grant SA Characterization of  bionanocomposite scaffolds comprised of amine-functionalized  single-walled carbon nanotubes crosslinked to an acellular porcine  tendon. J Biomed Mater Research: Part A (2011) Mar; 96(3)584-594 PubMed  PMID: 21254390

Deeken CR,  Fox DB, Bachman SL, Ramshaw BJ, Grant SA Characterization of  bionanocomposite scaffolds comprised of amine-functionalized gold  nanoparticles and silicon carbide nanowires crosslinked to an acellular  porcine tendon. J Biomed Mater Research: Part B (2011) May; 97B: 334-344  PubMed PMID: 21394904

Deeken CR,  Bachman SL, Ramshaw BJ, Grant SA Characterization of bionanocomposite  scaffolds comprised of mercaptoethylamne-functionalized gold  nanoparticles crosslinked to acellular porcine tissue. J Mater Sci:  Mater Med (2012) 23:537-546 PubMed PMID: 22071985

Ebersole GC, Buettmann EG, MacEwan MR, Tang ME, Frisella MM, Matthews BD, Deeken CR Development  of novel electrospun absorbable polycaprolactone (PCL) scaffolds for  hernia repair applications. Surg Endosc (2012) 26:2717-2728

Grant SA, Deeken CR,  Hamilton SR, Grant DA, Bachman SL, Ramshaw BJ. A comparative study of  the remodeling and integration of a novel AuNP-tissue scaffold and  commercial tissue scaffolds in a porcine model. J Biomed Mater Res A.  2013 Oct; 101(10):2778-2787 PubMed PMID: 23436761

CLINICAL STUDIES

Saettele TM, Bachman SL, Costello CR,  Grant SA, Cleveland DS, Loy TS, Kolder DG, Ramshaw BJ Use of porcine  dermal collagen as a prosthetic mesh in a contaminated field for ventral  hernia repair: A case report. Hernia (2007) June;11(3):279-285 PubMed  PMID: 17279319

Brown SR, Melman L, Jenkins ED, Deeken CR,  Frisella MM, Brunt LM, Eagon JC, Matthews BD Collagen type I:III ratio  of the gastroesophageal junction in patients with paraesophageal  hernias. Surg Endosc (2011) 25:1390-1394 (PMCID: PMC3785291)

Ward KC, Costello KP, Baalman S, Pierce RA, Deeken CR,  Frisella MM, Brunt LM, Matthews BD Effect of acellular human dermis  buttress on laparoscopic hiatal hernia repair. Surg Endosc (2015) Aug  29(8):2291-2297

​Miller JR, Deeken CR,  Ray S, Henn MC, Lancaster TS, Schuessler RB, Damiano RJ, Melby SJ.  Expanded polytetrafluoroethylene for chordal replacement: Preventing  knot failure. Ann Thorac Surg (2015) Dec; 100(6)2325-2329. PubMed PMID:  26652523

​Gretsch KF, Lather HD, Peddada KV, Deeken CR,  Wall LB, Goldfarb CA. Development of novel 3-D printed robotic  prosthetic for transradial amputees. Prosthet Orthot Int (2016) Jun;  40(3):400-403. 

​Brown SR, Cleveland EM, Deeken CR,  Huitron SS, Aluka KJ, Davis KG. TypeI/type III collagen ration  associated with diverticulitis of the colon in young patients. J Surg  Res (2017) Jan;207:229-234. PubMed PMID: 27979482

Roth  JS, Anthone GJ, Selzer DJ, Poulose BK, Bittner JG, Hope WW, Dunn RM,  Martindale RG, Goldblatt MI, Earle DB, Romanelli JR, Mancini GJ,  Greenberg JA, Linn JG, Parra-Davila E, Sandler BJ, Deeken CR,  Voeller GR. Prospective evaluation of poly-4-hydroxybutyrate mesh in  CDC class I/high risk ventral and incisional hernia repair: 18 months  follow-up. Surg Endosc (2018) Apr;32(4):1929-1936 

BOOK CHAPTERS

Cavallo, JA, Deeken, CR,  Matthews, BD. In B. Jacob & B. Ramshaw (Eds.), Biologic Mesh: When  and Why: A Critical Appraisal The SAGES Manual of Hernia Repair.  Springer Publishing Company; 2013

Deeken CR.  In B. Heniford & Y. Novitsky (Eds.), Biologic mesh: classification  and evidence-based critical appraisal in Current Principles of Surgery  of the Abdominal Wall. Springer Publishing Company; 2015

Deeken CR,  Lake SP. In S. S. Davis, G. Dakin, & A Bates (Eds.), Fundamentals  of prosthetic characteristics in The SAGES Manual of Hernia Surgery,  Springer Science, 2018